Effect of carvedilol on atrial excitation-contraction coupling, Ca2+ release, and arrhythmogenicity
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چکیده
منابع مشابه
L-type Ca2+ current and excitation-contraction coupling in single atrial myocytes from rainbow trout.
We have examined the contribution of L-type Ca2+ current ( I Ca) to the activation of contraction in trout atrial myocytes under basal and phosphorylating conditions. The average myocyte length was 197 ± 14 μm, width was 5.5 ± 0.2 μm, and cell capacitance was 36.2 ± 2.2 pF. With 25 μM EGTA in the patch pipette and a stimulation frequency of 0.125 Hz, I Cawas 2.6 ± 0.4 pA/pF and it carried a tot...
متن کاملK201 modulates excitation-contraction coupling and spontaneous Ca2+ release in normal adult rabbit ventricular cardiomyocytes.
OBJECTIVES The drug K201 (JTV-519) increases inotropy and suppresses arrhythmias in failing hearts, but the effects of K201 on normal hearts is unknown. METHODS The effect of K201 on excitation-contraction (E-C) coupling in normal myocardium was studied by using voltage-clamp and intracellular Ca(2+) measurements in intact cells. Sarcoplasmic reticulum (SR) function was assessed using permeab...
متن کاملPredetermined recruitment of calcium release sites underlies excitation-contraction coupling in rat atrial myocytes.
Excitation-contraction coupling (E-C coupling) was studied in isolated fluo-3-loaded rat atrial myocytes at 22 and 37 degrees C using rapid confocal microscopy. Within a few milliseconds of electrical excitation, spatially discrete subsarcolemmal Ca2+ signals were initiated. Twenty to forty milliseconds after stimulation the spatial overlap of these Ca2+ signals gave a 'ring' of elevated Ca2+ a...
متن کاملThe intricacies of atrial calcium cycling during excitation-contraction coupling
Introduction In the heart, excitation-contraction coupling (ECC) is a sequence of events that begins with membrane depolarization by an action potential (AP), followed by activation of voltage-gated Ca channels in the surface membrane, initiation of Ca release from the SR Ca store by CICR, and the resulting contraction. Most of our knowledge of the mechanistic details of ECC originates from stu...
متن کاملIP3 receptor-dependent Ca2+ release modulates excitation-contraction coupling in rabbit ventricular myocytes.
Inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R)-dependent Ca(2+) signaling exerts positive inotropic, but also arrhythmogenic, effects on excitation-contraction coupling (ECC) in the atrial myocardium. The role of IP(3)R-dependent sarcoplasmic reticulum (SR) Ca(2+) release in ECC in the ventricular myocardium remains controversial. Here we investigated the role of this signaling pathway ...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2020
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.00650.2019